BDB564184
VHL Mouse anti-Human, Alexa Fluor 647, Clone: S2-647, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB564184-Each-of-1 | In Stock | ₹ 25,409.50 |
BDB564184 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,409.50
GST (18%): ₹ 4,573.71
Total Price: ₹ 29,983.21
Antigen
VHL
Classification
Monoclonal
Conjugate
Alexa Fluor 647
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG2b κ
Applications
Flow Cytometry
Clone
S2-647
Description
VHL1; pVHL; Elongin binding protein; Protein G7; HRCA1; RCA1
Immunogen
Human VHL Recombinant Protein
Quantity
50 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The S2-647 monoclonal antibody recognizes the Von Hippel-Lindau (VHL) protein
- The VHL protein is expressed within the cytosol and nuclei of cells from a variety of tissues
- It serves as a tumor suppressor and transcriptional repressor that is highly conserved from Drosophila to mammalian species
- VHL binds to Elongin B and C subunits and other proteins as part of a E3 ubiquitin ligase complex that targets a variety of proteins, including HIF-1 alpha and Beta-2 adrenergic receptors, for proteasomal degradation
- Aberrant VHL expression is associated with a number of diseases including Von Hippel-Lindau disease, a familial cancer syndrome, that predisposes individuals to hemangioblastomas of the central nervous system and retina, pheochromocytoma and renal cell carcinoma
- Three distinct VHL isoforms ranging in molecular weight from approximately 19-30 kDa have been described.