BDB564215
TLR4 (CD284) Mouse anti-Human, PE, Clone: TF901, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB564215-Each-of-1 | In Stock | ₹ 24,875.50 |
BDB564215 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 24,875.50
GST (18%): ₹ 4,477.59
Total Price: ₹ 29,353.09
Antigen
TLR4 (CD284)
Classification
Monoclonal
Conjugate
PE
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
TF901
Description
TLR4; CD284; Toll-like Receptor 4; ARMD10
Immunogen
Human TLR4 Transfected Cell Line
Quantity
100 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The TF901 monoclonal antibody specifically binds to TLR4 (Toll-like receptor 4) which is also known as CD284
- TLR4 is a 110 kDa type I transmembrane glycoprotein that belongs to the Toll-like receptor (TLR) family
- TLR4 is expressed on monocytes, macrophages, granulocytes, dendritic cells and endothelial cells
- TLR4 binds lipopolysaccharide (LPS) which is a major membrane component of Gram-negative bacteria
- It thus acts as an innate immune recognition receptor against many pathogens
- In association with MD-2, LPS binds to and signals through TLR4 receptors by MyD88-dependent and MyD88-independent pathways to induce the cellular production of proinflammatory cytokines
- TF901 antibody binding is not influenced by the human TLR4 D299G/T399I polymorphism
- Preincubation of TLR4-positive cells with the TF901 antibody blocks the subsequent binding of the HTA125 antibody which is also specific for human TLR4.