BDB610031
ERK1 Mouse, Unlabeled, Clone: MK12, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB610031-Each-of-1 | In Stock | ₹ 47,036.50 |
BDB610031 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
ERK1
Classification
Monoclonal
Concentration
250μg/mL
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen
Rat ERK1 aa. 325 to 345
Quantity
150 μg
Research Discipline
Cell Biology
Target Species
Canine, Chicken, Frog, Human, Mouse, Rat
Isotype
IgG1
Applications
Western Blot
Clone
MK12
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- The family of serine/threonine kinases known as ERKs (extracellular signal regulated kinases) or MAPKs (mitogen-activated protein kinases) is activated after cell stimulation by a variety of hormones and growth factors
- Cell stimulation induces a signaling cascade that leads to phosphorylation of MEK (MAPK/ERK kinase) which, in turn, activates ERK via tyrosine and threonine phosphorylation
- A myriad of proteins represent the downstream effectors for the active ERK and implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton
- Activation of ERK is normally transient and cells possess dual specificity phosphatases that are responsible for its down-regulation
- Furthermore, multiple studies have shown that elevated ERK activity is associated with some cancers
- ERK1 is a 44 kDa member of the ERK family and shares 85% homology with ERK2 (42 kDa).