BDB610153
β-Catenin Mouse, Unlabeled, Clone: 14, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB610153-Each-of-1 | In Stock | ₹ 25,454.00 |
BDB610153 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,454.00
GST (18%): ₹ 4,581.72
Total Price: ₹ 30,035.72
Antigen
β-Catenin
Classification
Monoclonal
Concentration
250μg/mL
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen
Mouse β-Catenin aa. 571-781
Quantity
50 μg
Research Discipline
Cell Biology
Target Species
Canine, Chicken, Human, Mouse, Rat
Isotype
IgG1
Applications
Western Blot
Clone
14
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- β-Catenin is a 92kDa protein that binds to the cytoplasmic tail of E-Cadherin
- The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions (zonula adherens)
- Deletions in the cytoplasmic domain of E-Cadherin which eliminate catenin binding also result in a loss of cell adhesion, indicating that this binding is essential for E-Cadherin function
- Although the α- and β-Catenins have been cloned, very little is known about their biochemical roles
- However a link between β-Catenin and colon cancer has been described
- β-Catenin was found to co-immunoprecipitate with the APC tumor suppressor protein in human colorectal tumor cell lines, as well as in human kidney 293 cells
- E-Cadherin, however, was not detectable in these complexes
- Thus the APC-Catenin complex may be affecting the transmission of contact inhibition signals and/or the regulation of cell adhesion
- Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting