RIG-I Recombinant Rabbit Monoclonal Antibody (7F6), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA549920-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA549920 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
RIG-I
Classification
Recombinant Monoclonal
Concentration
3 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
O95786
Gene Symbols
DDX58
Immunogen
A synthesized peptide derived from human DDX58
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Immunohistochemistry (Paraffin)
Clone
7F6
Conjugate
Unconjugated
Gene
DDX58
Gene Alias
6430573D20Rik, C330021E21, Ddx58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, DEAD box protein 58, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, DEAD/H box polypeptide RIG-I, DEAD-box protein 58, DEXD/H-box helicase 58, probable ATP-dependent RNA helicase DDX58, Retinoic acid-inducible gene 1 protein, retinoic acid-inducible gene I protein, retinoic acid-inducible gene-I, RIG-1, RIGI, RIG-I, RIG-I-like receptor 1, RLR-1, RNA helicase RIG-I, SGMRT2
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23586
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- Retinoic acid-inducible gene I, RIG-I is a pattern recognition receptor (PRR) involved in the recognition of viral dsRNA
- Along with MDA5, RIG-I detects viral dsRNA and activates the innate immune response
- Both MDA5 and RIG-I are RNA helicases and they perform overlapping as well as distinct roles
- RIG-I is activated by dsRNAs without a 5'-triphosphate end and short dsRNAs, whereas MDA5 is activated by long dsRNAs
- Once activated, both proteins signal through IPS-1 activating transcription factors NF-kappaB and IRF-3 (1) and μgtimately activating apoptosis, cytokine signaling, and inflammation
- RIG-I is essential for signaling by influenza A, influenza B, human respiratory syncytial virus (3), paromyxoviruses, Japanese encephalitis virus, and West Nile virus
- MicroRNA-146a has been implicated in feedback inhibition of RIG-I-dependant antiviral response by negatively regulating RIG-I targets TRAF6, IRAK1, and IRAK2
- Recent evidence has implicated RIG-I in the detection of cytosolic DNA through RNA polymerase III activity.