CD74 Recombinant Human Monoclonal Antibody (6B4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA549979-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA549979 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
CD74
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.03% Proclin 300, pH 7.4
Gene Accession No.
P04233
Gene Symbols
CD74
Immunogen
Recombinant Human CD74 protein
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Neutralization
Clone
6B4
Conjugate
Unconjugated
Gene
CD74
Gene Alias
CD74, CD74 antigen, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), CD74 molecule, Cd74 molecule, major histocompatibility complex, class II invariant chain, class II-associated invariant chain peptide, CLIP, DHLAG, dinucleotide microsatellite, gamma chain of class II antigens, H-2 class II histocompatibility antigen gamma chain, histocompatibility: class II antigens, gamma chain of, HLA class II histocompatibility antigen gamma chain, HLADG, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, ia antigen-associated invariant chain, Ia-associated invariant chain, Ia-GAMMA, Ii, invariant polypeptide of major histocompatibility complex, class II antigen-associated, INVG34, MHC class II-associated invariant chain, MHC HLA-DR gamma chain, p33
Host Species
Human
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
972
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG1
Related Products
Description
- HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB)
- The alpha chain gene contains 5 exons
- Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail
- DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5
- Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities
- Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation
- HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes
- Three loci, DR, DQ and DP, encode the major expressed products of the human class II region
- The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.