MST2 Recombinant Rabbit Monoclonal Antibody (3C3), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA549986-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA549986 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
MST2
Classification
Recombinant Monoclonal
Concentration
0.4 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
Q13188
Gene Symbols
STK3
Immunogen
A synthesized peptide derived from human STK3
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Western Blot
Clone
3C3
Conjugate
Unconjugated
Gene
STK3
Gene Alias
0610042I06Rik, KB-1458E12.1, KRS1, Mammalian STE20-like protein kinase 2, mess1, MST, Mst2, MST-2, MST2/C, MST2/N, Mst3, protein kinase homolog, serine/threonine kinase 3, serine/threonine kinase 3 (STE20 homolog, yeast), serine/threonine kinase 3 (Ste20, yeast homolog), serine/threonine-protein kinase 3, Serine/threonine-protein kinase 3 20kDa subunit, Serine/threonine-protein kinase 3 36kDa subunit, Serine/threonine-protein kinase Krs-1, Ste20, STE20-like kinase MST2, STK3, wu:fc19e11, zgc:55383
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6788
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways, and is known to be activated by the proapoptotic stimuli staurosporine and FAS ligand
- STK3 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation
- It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
- STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.