IL-12/IL-23 p40 Recombinant Human Monoclonal Antibody (14D4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550085-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA550085 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
IL-12/IL-23 p40
Classification
Recombinant Monoclonal
Concentration
0.1 mg/mL
Formulation
PBS with 50% glycerol and 0.03% Proclin 300, pH 7.4
Gene Accession No.
P29459, P29460, Q9NPF7
Gene Symbols
IL12A, IL12B, Il23a
Immunogen
Recombinant Human IL12&IL23 protein
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Neutralization
Clone
14D4
Conjugate
Unconjugated
Gene
IL12B
Gene Alias
CLMF, CLMF p35, CLMF p40, CLMF2, cytotoxic lymphocyte maturation factor 1, p35, cytotoxic lymphocyte maturation factor 35 kDa subunit, Cytotoxic lymphocyte maturation factor 40 kDa subunit, il 12, IL 12/IL 23p40, il 23, IL 23 p40, Il12, Il-12 p35, IL12 p40, IL23, IL-12 subunit p35, IL-12 subunit p40, IL-12, subunit p35, IL12, subunit p40, Il12a, IL-12A, Il12b, IL-12B, IL12p35, IL-12p35, Il12p40, Il-12p40, il23, IL-23, IL23 p41, IL-23 subunit alpha, Il23a, IL-23A, IL-23-A, IL23P19, IL-23p19, IL35 subunit, ILN, IMD28, IMD29, Interleukin, Interleukin 12, interleukin 12 35 kDa subunit, interleukin 12 35kDa subunit, interleukin 12 40 kDa subunit, interleukin 12 40kDa subunit, interleukin 12 p35 subunit, interleukin 12 polypeptide 35, interleukin 12 subunit p40, interleukin 12, p35, interleukin 12, p40, interleukin 12A, interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35), interleukin 12b, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40), interleukin 23 p19 subunit, interleukin 23 subunit alpha, interleukin 23, alpha subunit p19, Interleukin12, interleukin-12 alpha chain, interleukin-12 beta chain, interleukin-12 p40, interleukin-12 p40 subunit, interleukin-12 subunit alpha, Interleukin-12 subunit beta, interleukin-12 subunit p40, interleukin-23 p19 subunit, interleukin-23 p40 subunit, interleukin-23 subunit alpha, Interleukin-23 subunit p19, interleukin-six, G-CSF related factor, JKA3 induced upon T-cell activation, Ll12a, natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35, natural killer cell stimulatory factor, 40 kD subunit, NF cell stimulatory factor chain 1, NFSK, NK cell stimulatory factor chain 1, NK cell stimulatory factor chain 2, NKSF, NKSF1, NKSF2, p19, P35, p40, RP23-388G23.1, SGRF, UNQ2498/PRO5798
Host Species
Human
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3592, 3593, 51561
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG1
Related Products
Description
- IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation
- IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40)
- IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit
- Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue
- In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.