NeuN Recombinant Rabbit Monoclonal Antibody (HL2194), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550427-Each-of-1 | In Stock | ₹ 41,385.00 |
FEMA550427 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,385.00
GST (18%): ₹ 7,449.30
Total Price: ₹ 48,834.30
Antigen
NeuN
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
Q8BIF2
Gene Symbols
RBFOX3
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human NeuN. The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse, Rat
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Clone
HL2194
Conjugate
Unconjugated
Gene
RBFOX3
Gene Alias
D11Bwg0517e, FLJ56884, FLJ58356, fox 1 homolog (C. elegans) 3, fox1 homolog C, Fox-1 homolog C, FOX3, FOX-3, FOX3NeuN, hexaribonucleotide binding protein 3, hexaribonucleotide binding protein 3 (HRNBP3), Hexaribonucleotide-binding protein 3, Hrnbp3, NEUN, NeuN antigen, Neuna60, neuronal nuclear antigen A60, neuronal nuclei, Neuronal nuclei antigen, RBFOX3, RFOX3, RGD1560070, RNA binding fox-1 homolog 3, RNA binding protein, RNA binding protein fox-1 homolog 3, RNA binding protein, fox-1 homolog (C. elegans) 3, RNA binding protein, fox-1 homolog 3
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
287847, 52897
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Fox-3, also known as NEUN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein that contains one RRM (RNA recognition motif) domain
- Localized to both the nucleus and cytoplasm, Fox-3 is suggested to regulate alternative splicing events
- Fox-3 is encoded by a gene located on human chromosome 17, which is comprised over 2.5% of the human genome and encodes over 1,200 genes
- Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1
- Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death
- Malfunction or loss of p53 expression is associated with malignant cell growth and LiFraumeni syndrome
- Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.