RMP Recombinant Rabbit Monoclonal Antibody (PD00-48), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550721-Each-of-1 | In Stock | ₹ 42,275.00 |
FEMA550721 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,275.00
GST (18%): ₹ 7,609.50
Total Price: ₹ 49,884.50
Antigen
RMP
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
O94763
Gene Symbols
Uri1
Immunogen
Synthetic peptide aa 1-535/535.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunohistochemistry (Paraffin)
Clone
PD00-48
Conjugate
Unconjugated
Gene
Uri1
Gene Alias
C19orf2, C80913, FLJ10575, Nnx3, Ppp1r19, Protein NNX3, Protein phosphatase 1 regulatory subunit 19, protein phosphatase 1, regulatory subunit 19, RMP, RNA polymerase II subunit 5-mediating protein, RPB5-mediating protein, Unconventional prefoldin RPB5 interactor, unconventional prefoldin RPB5 interactor 1, URI, Uri1, URI1 prefoldin-like chaperone, URI1, prefoldin like chaperone, URI1, prefoldin-like chaperone
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
8725
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
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Description
- Positive control: Human colon carcinoma tissue, human ovary carcinoma tissue
- Predicted band size: 60 kDa Subcellular Location: Nucleus, Cytoplasm, Mitochondrion, Cell projection
- Involved in gene transcription regulation
- Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription
- May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells
- Required for cell survival in ovarian cancer cells
- Together with UXT, associates with chromatin to the NKX3-1 promoter region
- Antagonizes transcriptional modulation via hepatitis B virus X protein
- Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling
- The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors
- Mediates inhibition of PPP1CC phosphatase activity in mitochondria
- Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner
- Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination
- [Uniprot]