PSME2 Recombinant Rabbit Monoclonal Antibody (PSH0-10), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550771-Each-of-1 | In Stock | ₹ 42,275.00 |
FEMA550771 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,275.00
GST (18%): ₹ 7,609.50
Total Price: ₹ 49,884.50
Antigen
PSME2
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P97372, Q63798, Q9UL46
Gene Symbols
PSME2
Immunogen
Recombinant protein within human aa 2-239/239.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
PSH0-10
Conjugate
Unconjugated
Gene
PSME2
Gene Alias
11S regulator complex beta subunit, 11S regulator complex subunit beta, AA589371, Activator of multicatalytic protease subunit 2, AI788882, cell migration-inducing protein 22, MCP activator, 31-kD subunit, PA28b, Pa28b1, PA28beta, protease (prosome, macropain) 28 subunit, beta, proteasome (prosome, macropain) 28 subunit, beta, proteasome (prosome, macropain) activator subunit 2, proteasome (prosome, macropain) activator subunit 2 (PA28 beta), proteasome activator 28 subunit beta, proteasome activator 28-beta, proteasome activator complex subunit 2, proteasome activator hPA28 subunit beta, proteasome activator subunit 2, Psme2, REGbeta, REG-beta
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
19188, 29614, 5721
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Positive control: PC-12 cell lysate, 293T cell lysate, mouse liver tissue lysate, rat thymus tissue lysate, MCF-7 cell lysate, PC-3 cell lysate, Hela, rat stomach tissue, human rectal carcinoma tissue, HepG2
- Predicted band size: 27 kDa Subcellular Location: Cytosol, Extracellular region or secreted, Nucleus
- Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors
- The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus
- Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum
- The 26S proteasome is an ATP-dependent, multisubunit (approximately 31), barrel-shaped molecular machine with an apparent molecular weight of approximately 2.5 MDa
- It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes
- The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit
- An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation
- Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway
- Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.