ATP6AP1 Monoclonal Antibody (5G12A4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA548380-Each-of-1 | In Stock | ₹ 43,565.50 |
FERMA548380 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,565.50
GST (18%): ₹ 7,841.79
Total Price: ₹ 51,407.29
Antigen
ATP6AP1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
Q15904
Gene Symbols
ATP6AP1
Immunogen
Purified recombinant fragment of human ATP6AP1 (AA: 51-151) expressed in E. Coli.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Clone
5G12A4
Conjugate
Unconjugated
Gene
ATP6AP1
Gene Alias
16A; Ac45; AI316502; Atp6ap1; ATP6IP1; Atp6s1; ATPase H+ transporting accessory protein 1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1; ATPase, H+ transporting, lysosomal interacting protein 1; AW108110; C7-1; C7-1 protein; CF2; H-ATPase subunit; mFLJ00383; MGC129781; protein C7-1; Protein XAP-3; vacuolar H+ ATPase accessory subunit 1; vacuolar proton pump subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit Ac45; V-ATPase subunit S1; VATPS1; V-type proton ATPase subunit S1; XAP3; XAP-3
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
537
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG1
Related Products
Description
- Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles
- V-ATPases pump protons against an electrochemical gradient, thereby synthesizing ATP
- A peripheral V1 domain, which is responsible for ATP hydrolysis, and an integral V0 domain, which is responsible for proton translocation, compose the V-ATPase
- Nine subunits (A-H) make up the V1 domain and five subunits (a, d, c, c' and c"e"e) make up the V0 domain
- ATP6AP1 (ATPase, H+ transporting, lysosomal accessory protein 1), also known as 16A, CF2, Ac45, XAP3, ATP6S1, VATPS1 (vacuolar ATP synthase S1 accessory protein) or ATP6IP1, is a type I transmembrane, V-ATPase accessory protein that is predominantly expressed in endocrine and neuronal cells
- ATP6AP1 is responsible for targeting the V-ATPase enzyme to specialized complex vacuolar systems
- Via its cytoplasmic tail, ATP6AP1 interacts with subunits of the V0 domain
- The disruption of this interaction in osteoclasts results in impaired bone resorption, suggesting an important role for ATP6AP1 in proper osteoclastic bone resorption.