Integrin beta 1 (CD29) Monoclonal Antibody (BV7), FITC, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA549056-Each-of-1 | In Stock | ₹ 59,007.00 |
FERMA549056 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 59,007.00
GST (18%): ₹ 10,621.26
Total Price: ₹ 69,628.26
Antigen
Integrin beta 1 (CD29)
Classification
Monoclonal
Concentration
100 μg/mL
Formulation
PBS with 1% BSA and 0.02% sodium azide
Gene Accession No.
P05556
Gene Symbols
ITGB1
Immunogen
Human umbilical vein EC
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Flow Cytometry, Functional Assay, Immunoprecipitation, Inhibition Assays, Western Blot
Clone
BV7
Conjugate
FITC
Gene
ITGB1
Gene Alias
4633401G24Rik; AA409975; AA960159; Beta OL; beta oligodendroglia; CD29; CSAT antigen; ENSMUSG00000051907; Fibronectin receptor subunit beta; FNRB; Glycoprotein IIa; Gm9863; gpIIa; integrin beta 1; integrin beta 1 (fibronectin receptor beta); integrin beta 1A precursor; Integrin beta1; integrin beta-1; integrin beta-1 subunit; integrin beta1D; integrin precursor; integrin subunit beta 1; integrin VLA-4 beta subunit; integrin VLA-4 subunit beta; integrin, beta 1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITBG1D; ITGB1; JG22 antigen; MDF2; MSK12; RGD-receptor; very late activation protein, beta polypeptide; VLA-4 subunit beta; VLAB; VLA-BETA
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
3688
Content And Storage
4° C, store in dark
Isotype
IgG1
Related Products
Description
- BV7 binds to several other tumor cells (MG3 osteosarcoma, A375 melanoma, MHCC-1410 and Lovo colon carcinoma) but does not affect adhesion to endothelial cells
- ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein that is widely expressed by a variety of cells including all leucocytes
- ITGB1 forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CDa-f) determining the binding properties of beta1 (VLA) integrins
- ITGB1 is a cell adhesion molecule appearing on platelets, as the common Beta subunit of the very late activation antigen (VLA), and as a component of various protein complexes binding to extracellular matrix proteins
- Decreased expression of ITGB1 correlates with acquiring multidrug resistance of tumor cells in the presence of anti-tumor drug
- ITGB1 is up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue
- Further, ITGB1 also regulates tissue damage and disease symptoms related to inflammatory bowel disease
- Through an ITGB1-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta
- More than 8 beta subunits with numerous splice variant isoforms have been identified in mammals
- There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids
- The distribution pattern in adult tissues for integrin beta types are mutually exclusive
- Beta1A is present in all tissues, except cardiac and skeletal muscle which express the beta1D variant.