Integrin beta 3 Monoclonal Antibody (BV4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA549057-Each-of-1 | In Stock | ₹ 51,397.50 |
FERMA549057 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,397.50
GST (18%): ₹ 9,251.55
Total Price: ₹ 60,649.05
Antigen
Integrin beta 3
Classification
Monoclonal
Concentration
100 μg/mL
Formulation
PBS with 0.1% BSA and no preservative
Gene Accession No.
P05106
Gene Symbols
ITGB3
Immunogen
The monoclonal antibody BV4 recognizes human beta3 integrin subunit present in Platelet glycoprotein GPIIb-IIIa (integrin alphaIIb/beta3, CD41/CD61) and in the vitronectin receptor (integrin alphaV/beta3, CD51/CD61)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Inhibition Assays, Western Blot
Clone
BV4
Conjugate
Unconjugated
Gene
ITGB3
Gene Alias
antigen CD61; BDPLT16; BDPLT2; beta3 integrin; CD61; EGK_08849; glycoprotein GPIIIa; glycoprotein IIIa; GP3A; GPIIIa; GT; INGRB3; integrin beta 3; integrin beta 3 (Cd61); integrin beta-3; integrin beta-3 subunit; integrin subunit beta 3; integrin, beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITGB3; platelet glycoprotein IIIa; platelet glycoprotein IIIa integrin subunit beta 3; platelet gpIIIa; platelet membrane glycoprotein IIIa
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
3690
Content And Storage
4° C
Isotype
IgG1
Related Products
Description
- CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors
- CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin
- CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface
- CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51
- CD61 is a receptor for fibrinogen, fibronectin, Von Willebrand Factor, vitronectin and thrombospondin
- The CD61 protein product is composed of an alpha chain and a beta chain
- A given chain may combine with multiple partners resulting in different integrins
- CD61 is found along with the alpha IIb chain in platelets
- Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling
- Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.