Podoplanin Monoclonal Antibody (4D5aE5E6), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA182747-Each-of-1 | In Stock | ₹ 59,185.00 |
MA182747 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 59,185.00
GST (18%): ₹ 10,653.30
Total Price: ₹ 69,838.30
Antigen
Podoplanin
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with <0.1% sodium azide
Gene Accession No.
Q86YL7
Gene Symbols
PDPN
Immunogen
ORF Human podoplanin ectodomain expressed in E.coli.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Clone
4D5aE5E6
Conjugate
Unconjugated
Gene
PDPN
Gene Alias
29kDa cytosolic podoplanin intracellular domain; Aggrus; CTA-520D8.1; E11; E11 antigen epitope; epithelial cell surface transmembrane protein antigen; glycoprotein 36; Glycoprotein 38; glycoprotein, 36-KD; GP36; Gp38; GP40; HT1A-1; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); Ots8; OTS-8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26; PA2.26 antigen; PDPN; PICD; Podoplanin; PSEC0003; PSEC0025; pulmonary type I alveolar epithelial cell transmembrane differentiation marker; RANDAM-2; RP23-348F1.2; RTI140; RTI40; T1a; T1A2; T1A-2; T1alpha; T1-alpha; TI1A; Transmembrane glycoprotein E11; type I cell 40 kDa protein
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
10630
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections
- A suggested positive control for immunohistochemical applications is normal lung
- Mouse anti Human podoplanin antibody, clone 4D5aE5E6 recognizes human podoplanin also known as gp36, Aggrus, PA2.26 antigen or T1 alpha
- Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight
- Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs
- Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells
- As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes
- Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential
- Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue
- Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells
- Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC
- Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm
- Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.