Syk Recombinant Rabbit Monoclonal Antibody (PSH0-76), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA549362-Each-of-1 | In Stock | ₹ 39,605.00 |
FERMA549362 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,605.00
GST (18%): ₹ 7,128.90
Total Price: ₹ 46,733.90
Antigen
Syk
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P43405
Gene Symbols
Syk
Immunogen
Synthetic peptide within human aa 451-500 / 635.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Clone
PSH0-76
Conjugate
Unconjugated
Gene
Syk
Gene Alias
DKFZp313N1010, EC 2.7.10.2, FLJ25043, FLJ37489, HGNC:11205, kinase Syk, KSYK, p72Syk, p72-Syk, ptk72, SP1, spleen associated tyrosine kinase, spleen tyrosine kinase, SYK, syk signaling, Sykb, tyrosine-kinase syk, tyrosine-protein kinase SYK
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
6850
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Related Products
Description
- Sequence Similarities: 100% Mouse
- Tissue Specificity: Widely expressed in hematopoietic cells (at protein level) (PubMed:8163536)
- Expressed in neutrophils (at protein level) (PubMed:15123770)
- Within the B-cell compartment, expressed from pro- and pre-B cells to plasma cells (PubMed:8163536)
- Positive Control: Raji cell lysate, Daudi cell lysate, SW620 cell lysate, Ramos cell lysate
- Subcellular Location: Cell membrane, Cytoplasm, cytosol
- Predicted band size: 72 kDa
- Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases
- SYK may also play a role in cancer
- Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes
- Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases
- These kinases also help to activate Syk by phosphorylation of its activation loop.