Hepatitis B Virus X Monoclonal Antibody (X36C), Invitrogen™

Description

• MA1-081 detects hepatitis B x (HBx) protein from transfected human cells
• MA1-081 has been successfully used in Western blot, immunoprecipitation and ELISA procedures
• By Western blot, this antibody detects a single ∽17 kDa protein representing HBx
• This antibody is not capable of immunoprecipitating HBx complexed with HBx interacting protein (XIP)
• The MA1-081 immunogen is baculovirus expressed recombinant HBx
• The hepatitis B virus is an important cause of acute and chronic liver disease
• It is also the most common form of parenterally transmitted viral hepatitis
• The Hepatitis B X antigen is a 154 amino acid ∽17 kDa multifunctional protein involved in the development of liver chirrosis and hepatocellular carcinoma
• The virus is estimated to affect some 350 million people worldwide
• Immunization against hepatitis B is an important component of preventative medicine and is offered to all children in approximately 30 countries
• Hepatitis B virus (HBV) belongs to the Hepadnaviridae family and infection with HBV is usually more serious than infection with hepatitis A virus
• In some individuals the infection is not cleared and followed by persistent intracellular viral carriage that can lead to the development of hepatocelular carcinomas
• There are currently 400 million HBV carriers worldwide making HBV one of the most common human pathogens.