Phospho-ATM (Ser1981) Monoclonal Antibody (10H11), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA12020-Each-of-1 | In Stock | ₹ 50,997.00 |
MA12020 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,997.00
GST (18%): ₹ 9,179.46
Total Price: ₹ 60,176.46
Antigen
Phospho-ATM (Ser1981)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
Q13315, Q62388
Gene Symbols
ATM
Immunogen
Synthetic peptide corresponding to residues S(1974) L A F E E S(p) Q S T T I S S(1988) of human ATM Kinase protein.
Quantity
200 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
10H11
Conjugate
Unconjugated
Gene
ATM
Gene Alias
AI256621; AT mutated; A-T mutated; A-T mutated homolog; AT mutated protein; AT1; ATA; Ataxia t; Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; Atm; ATM (phospho S1981); ATM (pS1981); ATM (pSer1981); ATM phospho S1981; ATM phospho Ser1981; ATM serine/threonine kinase; C030026E19Rik; DKFZp781A0353; EC 2.7.1.37; MGC74674; phospho ATM; phospho S1981 ATM; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
11920, 472
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- MA1-2020 detects the phospho-ATM kinase in human and mouse samples
- MA1-2020 has been successfully used in immunofluorescence, immunoprecipitation and Western blot procedures
- By Western blot this antibody detects a ∽370 kDa protein representing the phospho-ATM kinase in crude lysates from gamma irradiated HeLa cells
- In immunofluorescence procedures, MA1-2020 recognizes the phospho-ATM kinase in irradiated human and mouse fibroblasts
- The MA1-2020 immunogen is a phosphorylated synthetic peptide corresponding to the residues S(1974) L A F E E S(p) Q S T T I S S(1988) of human ATM Kinase protein
- Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family
- Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer
- The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily
- ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1
- The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens
- The ATM’s C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases)
- Studies have shown that ATM becomes autophosphorylated and upregulated by exposure to ionizing radiation
- AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction
- Further, DNA damage caused by ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair
- Studies have linked ATM to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.