ATM Monoclonal Antibody (3E8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA123154-Each-of-1 | In Stock | ₹ 47,481.50 |
MA123154 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
ATM
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.4
Gene Accession No.
Q13315, Q62388
Gene Symbols
ATM
Immunogen
Recombinant protein expressed in E. coli corresponding to amino acids 980-1512.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
3E8
Conjugate
Unconjugated
Gene
ATM
Gene Alias
AI256621; AT mutated; A-T mutated; A-T mutated homolog; AT mutated protein; AT1; ATA; Ataxia t; Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; Atm; ATM (phospho S1981); ATM (pS1981); ATM (pSer1981); ATM phospho S1981; ATM phospho Ser1981; ATM serine/threonine kinase; C030026E19Rik; DKFZp781A0353; EC 2.7.1.37; MGC74674; phospho ATM; phospho S1981 ATM; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
11920, 300711, 472
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recommended positive controls: Raji, HeLa, or Akata
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family
- Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer
- The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily
- ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1
- The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens
- The ATM’s C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases)
- Studies have shown that ATM becomes autophosphorylated and upregulated by exposure to ionizing radiation
- AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction
- Further, DNA damage caused by ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair
- Studies have linked ATM to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.