THRB Monoclonal Antibody (J52), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA1216-Each-of-1 | In Stock | ₹ 49,973.50 |
MA1216 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,973.50
GST (18%): ₹ 8,995.23
Total Price: ₹ 58,968.73
Antigen
THRB
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
Gene Accession No.
P10828, P18113, P37242
Gene Symbols
THRB
Immunogen
Purified human TR beta -1 protein.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Gel Shift, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
J52
Conjugate
Unconjugated
Gene
THRB
Gene Alias
c-erbA-2; c-erbAbeta; C-ERBA-BETA; ERBA 2; ERBA BETA; ERBA2; ERBA-BETA; fj24f03; GRTH; LOW QUALITY PROTEIN: thyroid hormone receptor beta; MGC126109; MGC126110; NR1A2; Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; PRTH; RATT3REC; si:ch211-264a6.2; T3R[b]; T3Rbeta; T3rec; THR; THR1; thr2; Thrb; Thrb1; Thrb2; thyroid hormone nuclear receptor beta variant 1; thyroid hormone receptor beta; thyroid hormone receptor beta 1; thyroid hormone receptor beta 2; thyroid hormone receptor beta 3; thyroid hormone receptor beta1; thyroid hormone receptor beta-1; thyroid hormone receptor beta2; thyroid hormone receptor beta2delta; thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); TR; TR beta; TR beta 1; TR[b]1; trb; TR-B1C-ERBA-2; TRbeta; TR-beta; TRbeta1; TRbeta2Delta; wu:fj24f03
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
21834, 24831, 7068
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- MA1-216 detects thyroid hormone receptor (TR) beta-1 in human, mouse, rat, and transformed bacterial cells
- This antibody is specific for the TR beta-1 isoform
- MA1-216 has been successfully used in Western blot, immunocytochemistry, immunoprecipitation and gel shift procedures
- By Western blot, this antibody detects a 52 and a 55 kDa protein representing recombinant TR expressed in E
- coli
- The two different sizes represent two different translational starting points
- Immunocytochemical staining of TR beta-1 in intact GH3 cells with MA1-216 results in nuclear staining
- When levels of expression of the transfected receptor are high, cytoplasmic staining is seen along with nuclear staining
- Immunoprecipitation and gel super shift experiments show that MA1-216 reacts with the unliganded, liganded, and DNA binding forms of the receptor
- The MA1-216 immunogen is purified human TR beta-1 overexpressed in E
- coli
- This antibody recognizes an epitope in the A/B domain of human TR beta-1, amino acid residues 1-101
- Thyroid hormone receptors (TR), also known as c-erbA-2, are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences called hormone response elements following activation by the appropriate hormone
- Thyroid hormones, through their interaction with TR, effect metabolic processes, growth and development in many tissues by regulating the expression of genes for growth hormone, malic enzyme and several hepatic proteins
- There are two forms of TR; TR alpha (on chromosome 17) and TR beta (on chromosome 3)
- Each of these isoforms also has two isoforms; TR alpha-1 and TRv alpha-2, and TR beta-1 and TR beta-2 respectively
- TR alpha-1 and 2 are identical through amino acid 370 where their sequences diverge
- TRv alpha-2, which does not bind T3 and is a strong negative regulator of the functional TR, is 80 amino acids longer than TR alpha-1
- The corresponding gene for the thyroid hormone receptor beta-1 is NR1A2.