Estrogen Receptor beta Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1311-Each-of-1 | In Stock | ₹ 50,151.50 |
PA1311 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,151.50
GST (18%): ₹ 9,027.27
Total Price: ₹ 59,178.77
Antigen
Estrogen Receptor beta
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ESR2
Gene Alias
ER; ER beta; ER[b]; Erb; Erb2; Erbeta; ER-beta; Esr2; ESRB; ESR-BETA; ESTRB; estrogen receptor 2; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; estrogen receptor beta 1 isoform deletion variant; estrogen receptor beta 4; NR3A2; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; steroid receptor
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13983, 2100, 25149, 443066
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Gel Shift, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
O08537, Q62986, Q92731, Q9TU15
Gene Symbols
ESR2
Immunogen
Synthetic peptide corresponding to residues A(55) E P Q K S P W C E A R S L E H(70) of rat ER beta.
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Ovine, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-311 detects estrogen receptor (ER) beta from human, non-human primate, mouse, ovine and rat tissues
- PA1-311 has been successfully used in Western blot, immunocytochemistry and gel shift procedures
- By Western blot, this antibody detects an ∽55-62 kDa protein representing ER beta from rat brain homogenate
- PA1-311 efficiently supershifts rat ER beta/ER response element (vitellogenin xenopus A2 gene)
- The PA1-311 immunogen is a synthetic peptide corresponding to residues A(55) E P Q K S P W C E A R S L E H(70) of rat ER beta
- Recombinant ER beta expressed in baculovirus system (Cat
- # RP-311 and RP-312) can be purchased for control experiments in Western blot and gel shift assays
- PA1-311 can be used with blocking peptide PEP-011
- Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described
- Human ER beta was initially cloned and characterized from testis
- Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors
- The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA
- When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins
- There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively)
- Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha
- Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues
- ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.