THRB Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1213A-Each-of-1 | In Stock | ₹ 47,926.50 |
PA1213A - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,926.50
GST (18%): ₹ 8,626.77
Total Price: ₹ 56,553.27
Antigen
THRB
Classification
Polyclonal
Conjugate
Unconjugated
Gene
THRB
Gene Alias
c-erbA-2; c-erbAbeta; C-ERBA-BETA; ERBA 2; ERBA BETA; ERBA2; ERBA-BETA; fj24f03; GRTH; LOW QUALITY PROTEIN: thyroid hormone receptor beta; MGC126109; MGC126110; NR1A2; Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; PRTH; RATT3REC; si:ch211-264a6.2; T3R[b]; T3Rbeta; T3rec; THR; THR1; thr2; Thrb; Thrb1; Thrb2; thyroid hormone nuclear receptor beta variant 1; thyroid hormone receptor beta; thyroid hormone receptor beta 1; thyroid hormone receptor beta 2; thyroid hormone receptor beta 3; thyroid hormone receptor beta1; thyroid hormone receptor beta-1; thyroid hormone receptor beta2; thyroid hormone receptor beta2delta; thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); TR; TR beta; TR beta 1; TR[b]1; trb; TR-B1C-ERBA-2; TRbeta; TR-beta; TRbeta1; TRbeta2Delta; wu:fj24f03
Host Species
Rabbit
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG
Applications
Gel Shift, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
Conc. Not Determined
Formulation
whole serum diluted in PBS with 0.05% sodium azide
Gene Accession No.
P10828, P18113
Gene Symbols
THRB
Immunogen
Synthetic peptide corresponding to residues C-I(62) F H L D H D D V N D Q S V S S A Q T F(81) of human TR beta-1, with an N-terminal added cysteine.
Regulatory Status
RUO
Gene ID (Entrez)
24831, 7068
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- PA1-213A detects thyroid hormone receptor (TR) beta-1 from human and rat tissues
- This antibody does not detect TR alpha-1 or TRv alpha-2
- PA1-213A has been successfully used in Western blot, immunohistochemistry (paraffin), IF and gel shift procedures
- By Western blot, this antibody detects a ∽55 kDa protein representing recombinant human TRv beta-1 expressed in E
- coli
- PA1-213A immunizing peptide corresponds to residues 62-81 of human TR beta-1, with an N-terminal added cysteine
- Alternative numbering of this protein has this peptide corresponding to residues 67-86 of human TR beta-1
- This sequence is completely conserved between human and rat TR beta-1
- Thyroid hormone receptors (TR), also known as c-erbA-2, are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences called hormone response elements following activation by the appropriate hormone
- Thyroid hormones, through their interaction with TR, effect metabolic processes, growth and development in many tissues by regulating the expression of genes for growth hormone, malic enzyme and several hepatic proteins
- There are two forms of TR; TR alpha (on chromosome 17) and TR beta (on chromosome 3)
- Each of these isoforms also has two isoforms; TR alpha-1 and TRv alpha-2, and TR beta-1 and TR beta-2 respectively
- TR alpha-1 and 2 are identical through amino acid 370 where their sequences diverge
- TRv alpha-2, which does not bind T3 and is a strong negative regulator of the functional TR, is 80 amino acids longer than TR alpha-1
- The corresponding gene for the thyroid hormone receptor beta-1 is NR1A2.