TLR4 Monoclonal Antibody (HTA125), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA133380-Each-of-1 | In Stock | ₹ 46,947.50 |
MA133380 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,947.50
GST (18%): ₹ 8,450.55
Total Price: ₹ 55,398.05
Antigen
TLR4
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
O00206, P58727, Q68Y56, Q9QUK6
Gene Symbols
TLR4
Immunogen
Ba/F3 cell line expressing TLR4
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Canine, Feline, Guinea Pig, Human, Mouse, Non-human Primate, Porcine, Rhesus Monkey
Product Type
Antibody
Isotype
IgG2a
Applications
Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Neutralization
Clone
HTA125
Conjugate
Unconjugated
Gene
TLR4
Gene Alias
ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
100724803, 21898, 399541, 403417, 493698, 574360, 7099
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- MA1-33380 detects TLR4 from guinea pig, non-human primate, human, pig and cat samples
- TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity
- TLRs are highly conserved from Drosophila to humans and share structural and functional similarities
- This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes
- Mammalian cells respond to LPS by activating TLR4
- TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria
- TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity
- The various TLRs exhibit different patterns of expression
- Mutations in the TLR4 gene have been associated with differences in LPS responsiveness
- Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain
- TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta
- Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide
- Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.