Calnexin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA130197-Each-of-1 | In Stock | ₹ 54,646.00 |
PA130197 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 54,646.00
GST (18%): ₹ 9,836.28
Total Price: ₹ 64,482.28
Antigen
Calnexin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CANX
Gene Alias
1110069N15Rik; AI988026; calmegin; calnexin; canx; canx-a; canx-b; clgn; clnx; cnx; D11Ertd153e; FLJ26570; hypothetical protein; IP90; Major histocompatibility complex class I antigen-binding protein p88; p88; P90; PP90; pp90 precursor
Host Species
Rabbit
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Avian, Bovine, Guinea Pig, Hamster, Human, Mouse, Non-human Primate, Ovine, Porcine, Rabbit, Rat, X. laevis
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
whole serum with no preservative
Gene Accession No.
P27824, P35564, P35565
Gene Symbols
CANX
Immunogen
synthetic peptide TAPPSSPKVTYKAPVPTGE conjugated to KLH, corresponding to amino acids 50-68 of Human Calnexin
Regulatory Status
RUO
Gene ID (Entrez)
100341645, 100519184, 100689345, 100726237, 101122273, 101828013, 107320193, 12330, 29144, 407129, 448161, 821
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Positive control of heat shocked HeLa Cell lysate suggested
- Calnexin, also referred to as IP90, p88 and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER)
- Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins
- Studies indicate that calnexin associates with the major histocompatibility complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes
- It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER
- The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP78 and GRP94 and protein disulfide isomerase
- Integral membrane ER resident proteins, like calnexin, often lack this KDEL sequence but contain positively charged cytosolic residues that ensure ER retention
- Calnexin contains a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).