MA180133
CD68 Monoclonal Antibody (514H12), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA180133-Each-of-1 | In Stock | ₹ 25,854.50 |
MA180133 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,854.50
GST (18%): ₹ 4,653.81
Total Price: ₹ 30,508.31
Antigen
CD68
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
tissue culture supernatant with <0.1% sodium azide
Gene Accession No.
P34810
Gene Symbols
Cd68
Immunogen
Fusion protein of external domain of human CD68.
Regulatory Status
RUO
Gene ID (Entrez)
968
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Clone
514H12
Conjugate
Unconjugated
Gene
Cd68
Gene Alias
CD68; CD68 antigen; CD68 molecule; GP110; Lamp4; macrophage antigen CD68; macrosialin; Scard1; scavenger receptor class D, member 1; similar to CD68 antigen
Host Species
Mouse
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a
Related Products
Description
- Heat-mediated antigen retrieval using Tris/EDTA (pH 8) is recommended for the staining of paraffin sections
- The epitope recognized by clone 514H12 is sensitive to peroxide and so any peroxidase-blocking steps should be performed after incubation with this antibody
- A suggested positive control for immunohistochemical applications is human tonsil
- Mouse anti Human CD68 antibody, clone 514H12 recognizes the human CD68 cell surface antigen, a approximately 110 kDa glycoprotein primarily expressed by macrophages and monocytes
- CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes
- Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions
- CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma
- Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.