CFTR Monoclonal Antibody (CF3), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA1935-Each-of-1 | In Stock | ₹ 48,104.50 |
MA1935 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,104.50
GST (18%): ₹ 8,658.81
Total Price: ₹ 56,763.31
Antigen
CFTR
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
ascites with 0.05% sodium azide
Gene Accession No.
P13569, P26361
Gene Symbols
CFTR
Immunogen
Synthetic Peptide: G(103) R I I A S Y D P D N K E E R(117)
Regulatory Status
RUO
Gene ID (Entrez)
1080, 12638
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone
CF3
Conjugate
Unconjugated
Gene
CFTR
Gene Alias
ABC35; Abcc7; ATP Binding Cassette Superfamily C Member 7 (ABCC7); ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; ATP-binding cassette, subfamily c, member 7; AW495489; cAMP-dependent chloride channel; CF; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator homolog; cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7; dJ760C5.1; MRP7; RGD1561193; tcag7.78; TNR CFTR; TNR-CFTR
Host Species
Mouse
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgM
Related Products
Description
- MA1-935 detects cystic fibrosis transmembrane conductance factor (CFTR) in human and mouse tissues
- MA1-935 has been successfully used in Western blot, immunofluorescence and immunoprecipitation procedures
- By Western blot, this antibody detects a single ∽170 kDa protein representing CFTR in T84 whole cell extract
- Immunofluorescence staining of CFTR in mouse epithelial cells with MA1-935 results in cell surface staining, consistent with localization at the plasma membrane
- This antibody also detects one or more immunologically related proteins in mouse cell line Heb7a that does not contain CFTR mRNA
- MA1-935 can also be used to inhibit the epithelial uptake of S
- typhi in some mouse cell lines
- MA1-935 immunizing peptide corresponds to amino acid residues 103-117 found in the first extracellular loop of human and rabbit CFTR
- This sequence is highly conserved in mouse, sheep, cow, and Xenopus laevis
- Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel
- Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (delta F508) which results in abnormal chloride transport
- Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is
- One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S
- typhi intestinal submucosal uptake.