Androgen Receptor Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1110-Each-of-1 | In Stock | ₹ 52,866.00 |
PA1110 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,866.00
GST (18%): ₹ 9,515.88
Total Price: ₹ 62,381.88
Antigen
Androgen Receptor
Classification
Polyclonal
Conjugate
Unconjugated
Gene
AR
Gene Alias
AIS; Andr; androgen nuclear receptor variant 2; androgen receptor; androgen receptor (Testicular feminization), same as Tfm; androgen receptor splice variant 4b; Ar; AR8; AR-A; AW320017; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; RP11-383C12.1; SBMA; SMAX1; TFM; Variant AR45
Host Species
Rabbit
Quantity
200 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
Conc. Not Determined
Formulation
whole serum diluted in PBS with 0.05% sodium azide
Gene Accession No.
P10275, P15207, P19091
Gene Symbols
AR
Immunogen
Fusion protein containing residues 331-572 of human androgen receptor.
Regulatory Status
RUO
Gene ID (Entrez)
11835, 24208, 367
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- PA1-110 detects androgen receptor (AR) from human, primate, rat, and mouse tissues
- This antibody does not detect estrogen, progesterone, or glucocorticoid receptors
- PA1-110 has been successfully used in Western blot, immunocytochemistry, immunohistochemistry and immunoprecipitation procedures
- By Western blot, this antibody detects an ∽110 kDa protein representing AR from rat brain homogenate
- Immunohistochemical staining of AR in rat brain with PA1-110 results in intense nuclear staining
- For fixation of frozen sections, 2% paraformaldehyde + 15% picric acid solution in phosphate buffer, pH 7.4 is recommended
- The PA1-110 immunogen is a fusion protein containing residues 331-572 of human androgen receptor
- The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors
- The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain
- The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT)
- Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes
- The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis
- AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain
- Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase)
- The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor
- Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility
- Mutations in this gene are associated with complete androgen insensitivity (CAIS).