MilliporeSigma™ CIRP (CIRBP), Mouse, Unlabeled, Clone: 6C7.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABC1207-Each-of-1 | In Stock | ₹ 46,799.76 |
MABC1207 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,799.76
GST (18%): ₹ 8,423.957
Total Price: ₹ 55,223.717
Antigen
CIRP (CIRBP)
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q14011
Immunogen
GST-tagged recombinant human CIRP (CIRBP) internal fragment.
Quantity
100 μL
Research Discipline
Apoptosis & Cancer
Gene ID (Entrez)
NP_001271
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
6C7.1
Conjugate
Unconjugated
Gene
CIRBP, A18HNRNP, CIRP
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 6C7.1 is expected to recognize CIRP spliced isoforms 1 and 3 (UniProt Q14011). Cross-reactivity toward spliced isoform 2 is possible, but has not been confirmed.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Cold-inducible RNA-binding protein (UniProt Q14011; also known as A18 hnRNP, Glycine-rich RNA-binding protein CIRP) is encoded by the CIRBP (also known as A18HNRNP, CIRP) gene (Gene ID 1153) in human
- CIRP is an 18kDa RNA-binding protein with an RNA recognition motif (RRM; a.a
- 6-84) and a glycine-rich domain (a.a
- 92-158)
- CIRP migrates from nucleus to cytoplasm, where it mediates posttranscriptional regulation of target mRNAs
- Originally characterized and named as a cold-induced protein, CIRP exerts antiapoptotic and cell-protective effects in response to cold stress, as well as other stimuli such as UV irradiation and hypoxia
- CIRP is expressed in a broad range of tissues (e.g
- testis, brain, lung, kidney, liver, stomach, bone marrow, and heart) and upregulated CIRP levels have been reported in several types of cancers
- CIRP knockdown is reported to increase p53 level and enhance cancer cells chemo-sensitivity to DNA damage inducing drugs
- Likewise, CIRP overexpression results in p53 downregulation.