MilliporeSigma™ PRMT7, Mouse, Unlabeled, Clone: 7G11,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE357-Each-of-1 | In Stock | ₹ 40,292.08 |
MABE357 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
PRMT7
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG2b in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q9NVM4
Immunogen
GST-tagged full-length recombinant human PRMT7.
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_061896
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
7G11
Conjugate
Unconjugated
Gene
PRMT7, KIAA1933
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 7G1 was raised against the full-length 692-a.a. spliced isoform (UniProt Q9NVM4-1), reactivity toward the other three spliced isoforms reported by UniProt is possible, but has not been confirmed.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2b κ
Related Products
Description
- Protein arginine N-methyltransferase 7 (EC 2.1.1.321; UniProt Q9NVM4; also known as Histone-arginine N-methyltransferase PRMT7, [Myelin basic protein]-arginine N-methyltransferase PRMT7) is encoded by the PRMT7 (also known as KIAA1933) gene (Gene ID 54496) in human
- Mammalian protein arginine methyltransferases (PRMTs) catalyze the methylation of arginine residues on histone and non-histone proteins
- PRMTs are divided into three types based on their mode of activity
- Type I PRMTs (PRMT1–4, PRMT6, and PRMT8) transfer up to two methyl groups on the same terminal guanidino nitrogen of arginine to form ω-NG-monomethylarginine (MMA) and ω-NG,NG-asymmetric dimethylarginine (ADMA) residues
- Type II PRMTs (PRMT5 and PRMT9) transfer methyl groups on different terminal guanidino nitrogens to form μμα and ω-NG,N'G-symmetric dimethylarginine (SDMA) residues, while type III PRMT7 transfers only one single methyl group to form MMA residues
- PRMT7 is involved in mediating cellular resistance or sensitivity to cytotoxic agents, as well as in regulating male germline imprinted gene via interaction with CCCTC-binding factor-like protein (CTCFL)
- PRMT7 is also reported to inhibit neuronal cell differentiation through the repression of MLL4-dependent gene expression, implicating a role in a stem cell population maintenance and cancer development
- PRMT7 knockdown is shown to decrease breast cancer cell invasion in vitro and metastasis in vivo, while PRMT7 overexpression is shown to enhance the invasiveness of a non-aggressive breast cancer cell line by inducing the expression of MMP9
- Similar to PRMT9, but unlike other PRMTs, PRMT7 contains a duplicated methyltransferase domain (a.a
- 14-345 and 358-684), with the N-terminal MTase acting as a funtional AdoMet-binding domain and the C-terminal MTase domain serving a pseudodimer function, mimicking the homodimer formation of other PRMTs needed for subtrate processing
- Deletion of either domain in PRMT7 abolishes its activity.