MilliporeSigma™ Synaptotagmin-like Protein 4 (SYTL4), Mouse, Unlabeled, Clone: 7D2.2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1713MI-Each-of-1 | In Stock | ₹ 38,958.86 |
MABS1713MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,958.86
GST (18%): ₹ 7,012.595
Total Price: ₹ 45,971.455
Antigen
Synaptotagmin-like Protein 4 (SYTL4)
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q96C24
Immunogen
GST-tagged recombinant human synaptotagmin-like protein 4 (SYTL4) internal fragment.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_001123368
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
7D2.2
Conjugate
Unconjugated
Gene
SYTL4, SLP4
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 7D2.2 epitope resides within an internal region mostly missing in human spliced isoform 2. Reactivity toward isoform 2 has not been confirmed.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Synaptotagmin-like protein 4 (UniProt Q96C24; also known as Exophilin-2, Granuphilin) is encoded by the SYTL4 (also known as SLP4) gene (Gene ID 94121) in human
- SYLT4 belongs to the synaptotagmin-like protein family, which contains an N-terminal RabBD (Rab-binding) domain and two C-terminal C2 domains
- The characteristic feature of this family is the N-terminal domain, which is not found in other C-type tandem C2 proteins
- SYLT4 is detected close to the plasma membrane and on secretory granules
- Interacts with vesicles containing negatively charged phospholipids in a Ca2+-independent manner
- It can bind to both the GTP- and GDP-bound forms of Rab27A and inhibits a specific GTP/GDP exchange cycle required for dense-core vesicle exocytosis
- It is the first regulatory in the exocytosis pathway that functions by directly connecting Rab and SNARE
- It modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary
- It is not only essential for the docking of insulin granules, but also simultaneously imposes a fusion constraint on them through an interaction with syntaxin-1alpha fusion machinery.