MABC576MI
MilliporeSigma™ Mouse anti-HOIL-1, Clone: 2E2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABC576MI-Each-of-1 | In Stock | ₹ 43,318.08 |
MABC576MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,318.08
GST (18%): ₹ 7,797.254
Total Price: ₹ 51,115.334
Antigen
HOIL-1
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
RBCK1; C20orf18; RNF54; UBCE7IP3; XAP3; XAP4
Immunogen
GST-tagged recombinant protein corresponding to human HOIL-1 near the C-terminus.
Quantity
100 μg
Research Discipline
Apoptosis, Cancer
Gene ID (Entrez)
NP_006453
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunocytochemistry, Western Blot
Clone
2E2
Gene Accession No.
Q9BYM8
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse
Form
Purified
Related Products
Description
- Specifically detects HOIL-1 clone: 2E2 in Human, Mouse samples, and it is validated for Immunocytochemistry, Western Blotting RanBP-type and C3HC4-type zinc finger-containing protein 1 (UniProt Q9BYM8; also known as HOIL-1, HBV-associated factor 4, Heme-oxidized IRP2 ubiquitin ligase 1, Hepatitis B virus X-associated protein 4, RBCC protein interacting with PKC1, RING finger protein 54, Ubiquitin-conjugating enzyme 7-interacting protein 3) is encoded by the RBCK1 gene (also known as C20orf18, HOIL1, PBMEI, RBCK2, RNF54, UBCE7IP3, XAP3, XAP4, ZRANB4) (Gene ID 10616) in human
- The linear ubiquitin assembly complex (LUBAC) is comprised of two RING-IBR-RING (RBR)-containing E3 ligases, HOIL-1L and HOIP
- LUBAC conjugates a head-to-tail-linked linear polyubiquitin chain onto lysine residues on substrate proteins
- Ovarian tumor deubiquitinating enzyme (DUB) with linear linkage specificity (OTULIN/Gumby/FAM105B) and cylindromatosis (CYLD) are two DUBs that catalyze the cleavage linear polyubiquitin chains
- OTULIN and CYLD interact with the N-terminal PNGase/UBA or UBX (PUB) domain of HOIP and negatively regulate LUBAC-mediated cellular processes
- LUBAC is reported to suppress IFN-dependent antiviral activity by mediating TRIM25 degradation and competing against TRIM25 for RIG-I interaction.