MABN361MI
MilliporeSigma™ Mouse anti-VAPA, Clone: 7E10.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN361MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABN361MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
VAPA
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
VAPA; VAP33
Immunogen
GST-tagged recombinant protein corresponding to the C-terminal half of human VAPA.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_919415
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
7E10.1
Gene Accession No.
Q9P0L0
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse
Form
Purified
Related Products
Description
- Specifically detects VAPA clone: 7E10.1 in Human, Mouse samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting Vesicle-associated membrane protein-associated protein A (UniProt Q9P0L0; also known as 33kDa VAMP-associated protein, hVAP-33, VAMP-A, VAMP-associated protein A, VAP-33, VAP-A) is encoded by the VAPA (also known as VAP33) gene (Gene ID 9218) in human
- VAMP-associated proteins (VAPs) are type IV membrane proteins that are well conserved among species
- There exist three human VAPs encoded by two genes, with VAPA encoding VAP-A and VAPB encoding VAP-B and VAP-C
- VAPs generally localize at the endoplasmic reticulum (ER), although they are also reported to localize at other subcellular organelles in some species and cell types
- VAP-A contains a major sperm protein (MSP) domain at the N-terminal, followed by a coiled-coil domain, and a transmembrane (TM) domain
- VAPs were shown to have important roles in non-vesicular lipid transport, lipid metabolism, the regulation of ER structure, and the unfolded protein response through MSP domain-mediated interaction with FFAT motifs
- Oxysterol-binding protein (OSBP) is a cytosolic receptor of cholesterol and oxysterols
- OSBP is recruited to the ER by binding to the MSP domain of VAP-A, a process essential for the stimulation of sphingomyelin synthesis by 25-hydroxycholesterol.