MABC613MI
MilliporeSigma™ Mouse anti-B7-H6, Clone: 5.51.18,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABC613MI-Each-of-1 | In Stock | ₹ 44,393.20 |
MABC613MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,393.20
GST (18%): ₹ 7,990.776
Total Price: ₹ 52,383.976
Antigen
B7-H6
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
NCR3LG1; B7H6
Immunogen
Recombinant protein corresponding to the extracellular domain of human B7-H6.
Quantity
100 μg
Research Discipline
Apoptosis, Cancer
Gene ID (Entrez)
NP_001189368
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
5.51.18
Gene Accession No.
Q68D85
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
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Description
- Specifically detects B7-H6 clone: 5.51.18 in Human samples, and it is validated for Flow Cytometry B7-H6 (also known as B7 homolog 6 or Natural cytotoxicity triggering receptor 3 ligand 1) is a single-pass membrane protein encoded by the NCR3LG1 or B7H6 gene (Entrez Gene ID 374383) in human
- B7-H6 belongs to the B7 family of structurally related cell-surface ligands, which bind to receptors on lymphocytes that regulate immune responses
- The natural cytotoxicity receptor NCR3/NKp30 is involved in NK-cell–mediated killing of various tumor cell lines
- B7-H6 is identified as the NKp30 ligand on cancer cells, while normal tissues were reported to lack B7-H6 transcripts
- Decreased NKp30 expression is reported to correlate with poor prognosis and survival among patients with acute myeloid leukemia (AML)
- Class I histone deacetylases HDAC2 & HDAC3 are reported to be involved in B7-H6 transcription activation, and HDAC inhibitors are found to impair tumor cell recognition by NK cells
- This monoclonal antibody is suitable for flow cytometric analysis, but does not compete against NKp30 binding (PMID 23801635).