MABE1130
MilliporeSigma™ Mouse anti-Hsp70/Hsp72, Clone: 2H9,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1130-Each-of-1 | In Stock | ₹ 40,633.84 |
MABE1130 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,633.84
GST (18%): ₹ 7,314.091
Total Price: ₹ 47,947.931
Antigen
Hsp70/Hsp72
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
HSPA1A; HSP70-1
Immunogen
Bovine skeletal muscle Hsp70/Hsp72.
Quantity
100 μg
Research Discipline
Epigenetics and Nuclear Function
Gene ID (Entrez)
NP_776975.1
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Western Blot
Clone
2H9
Gene Accession No.
Q27975
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Bovine, Human
Form
Purified
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Description
- Specifically detects Hsp70/Hsp72 clone: 2H9 in Bovine, Human samples, and it is validated for Western Blotting Heat shock 70kDa protein 1A (UniProt Q27975; also known as Heat shock 70kDa protein 1, HSP70.1) is encoded by the HSPA1A (also known as HSP70-1) gene (Gene ID 281825 & 282254) in bovine species
- The mammalian HSP70 family consists of the mitochondrial HSP75, the endoplasmic HSP78, the cytoplasmic HSC70 (a.k.a
- HSC73 and HSP73) and its inducible counterpart HSP72 (a.k.a
- HSP70)
- The latter two have similar structures and properties, and both of them bind misfolded, newly synthesized polypeptides in an ATP-dependent manner, reflecting their chaperonic activity
- All cells constitutively express HSC70
- On the other hand, the expression of HSP72 in normal cells is mainly stress inducible, although constitutively high HSP72 expressions are observed in malignant human tumors of various origins
- The induced HSP72 expression enables stressed cells to better cope with the elevation of unfolded/denatured proteins and to prevent apoptosis under various stress conditions.