MABE903MI
MilliporeSigma™ Mouse anti-ACD, Clone: 1G10.3,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE903MI-Each-of-1 | In Stock | ₹ 41,813.98 |
MABE903MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,813.98
GST (18%): ₹ 7,526.516
Total Price: ₹ 49,340.496
Antigen
ACD
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
ACD; PIP1; PTOP; TINT1; TPP1
Immunogen
GST-tagged recombinant protein corresponding to human ACD.
Quantity
100 μg
Research Discipline
Epigenetics and Nuclear Function
Gene ID (Entrez)
NP_001075955
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG2a κ
Applications
Immunocytochemistry, Western Blot
Clone
1G10.3
Gene Accession No.
Q96AP0
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Specifically detects ACD clone: 1G10.3 in Human samples, and it is validated for Immunocytochemistry, Western Blotting Adrenocortical dysplasia protein homolog (also known as POT1 and TIN2 organizing protein or TIN2-interacting protein) is a nuclear protein encoded by the ACD gene in human (also known as PIP1, PTOP, TINT1, TPP1)
- It a component of the shelterin complex (telosome) and is involved in the regulation of telomere length and protection
- Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends
- Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance, and chromosome ends are inappropriately processed by DNA repair pathways
- The ACD-POT1 heterodimer is reported to enhance telomere elongation by increasing telomerase processivity (PMID 17237768).