MABE1040MI
MilliporeSigma™ Rat anti-Nup98, Clone: 2H10,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1040MI-Each-of-1 | In Stock | ₹ 36,371.63 |
MABE1040MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,371.63
GST (18%): ₹ 6,546.893
Total Price: ₹ 42,918.523
Antigen
Nup98
Classification
Monoclonal
Formulation
Purified rat monoclonal IgG2cκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
NUP98; ADAR2
Immunogen
GST-tagged recombinant protein corresponding to human Nup98 near the N-terminus.
Quantity
100 μg
Research Discipline
Epigenetics and Nuclear Function
Gene ID (Entrez)
NP_005378
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG2c κ
Applications
Immunocytochemistry, Western Blot
Clone
2H10
Gene Accession No.
P52948
Host Species
Rat
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Purified
Related Products
Description
- Specifically detects Nup98 clone: 2H10 in Human, Mouse, Rat samples, and it is validated for Immunocytochemistry, Western Blotting The human gene NUP98 (Gene ID 4928; Also known as ADAR2, ADIR2, NUP96, NUP196) encodes the nuclear pore complex protein Nup98-Nup96 (UniProt P52948; also known as GLFG-repeat containing nucleoporin, Nup98-Nup96), which is posttranslationally autocleaved to form Nup98 and Nup96
- Cleavage of the Nup98-96 linkage enhances the interaction between Nup98 and Nup96 and promotes localization of the two proteins to the nuclear pore complex (NPC)
- An alternative splice event generates a mRNA variant (isoform 3; also known as Nup98-specific 1), which expresses only the Nup98 portion of the Nup98-96 mRNA and allows the independent production of Nup98
- Unlike Nup96, Nup98 is known to exist in both NPC-bound and non-NPC-associated pool, where it may participate in gene transcription regulations
- Nup98 is reported to interact with histone-modifying enzymes CBP/p300 and histone deacetylases (HDACs) through its glycine-leucine-phenylalanine-glycine (GLFG) repeats
- NUP98 gene is also involved in chromosomal translocations, resulting in Nup98 translocation fusions identified as potent transcription factors that induce acute myeloid leukemia (AML) with a particularly poor patient prognosis.