MABE1052MI
MilliporeSigma™ GMPS, Mouse, Unlabeled, Clone: 1G6.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1052MI-Each-of-1 | In Stock | ₹ 36,371.63 |
MABE1052MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,371.63
GST (18%): ₹ 6,546.893
Total Price: ₹ 42,918.523
Antigen
GMPS
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P49915
Immunogen
GST-tagged recombinant human GMPS ATP-PPase domain fragment.
Quantity
100 μL
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_003866
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
1G6.1
Conjugate
Unconjugated
Gene
GMPS
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 1G6.1 targets an epitope within the GMPS ATP-PPase domain region present in both spliced isoforms of human GMPS reported by UniProt (P49915).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2; UniProt P49915; also known as Glutamine amidotransferase, GMP synthetase) is encoded by the GMPS gene (Gene ID 8833) in human
- De novo biosynthesis of Guanosine 5&prime-monophosphate (GMP) is accomplished by reactions catalyzed by several enzymes
- Inositol monophosphate (IMP) dehydrogenase 1 and 2 (IMPDH1 and IMPDH2) convert IMP into xanthosine monophosphate (XMP), GMP synthetase (GMPS) then converts XMP into GMP, while guanosine monophosphate reductase (GMPR) catalyzes the reversible conversion of GMP to IMP to fuel back into both the AMP and GMP synthesis pathways
- GMPS is a bifunctional two-domain N-type pyrophosphatase whose N-terminal glutaminase domain (a.a
- 27-216) generates ammonia from glutamine, while its C-terminal synthetase domain (a.a
- 27-435) adenylylates XMP on the xanthine C2 oxygen, thereby priming XMP for attack by a nitrogen nucleophile to form GMP
- Human GMPS activity is subjected to an allosteric regulation and displays positive cooperativity for the substrate XMP
- GMPS is normally sequestered in the cytoplasm, but translocates to the nucleus in response to genotoxic stress or nucleotide deprivation
- GMPS nuclear translocation plays an important role in USP7-mediated stabilization of p53, where p53 is transferred from MDM2 to the GMPS-USP7 deubiquitylation complex.