MilliporeSigma™ ABCA4, Mouse, Unlabeled, Clone: TMR1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN1775MI-Each-of-1 | In Stock | ₹ 39,245.44 |
MABN1775MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,245.44
GST (18%): ₹ 7,064.179
Total Price: ₹ 46,309.619
Antigen
ABCA4
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
F1MWM0
Immunogen
ABCA4 isolated from bovine retinas (Zhang, N., et al. (2015). Hum. Mol. Genet. 24(11):3220-3237).
Quantity
200 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_776646
Target Species
Human
Form
Purified
Applications
Immunofluorescence, Western Blot
Clone
TMR1
Conjugate
Unconjugated
Gene
ABCA4, ABCR
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone TMR1 immunostained retina cryosections from wild-type mice, but not retina from mice with homozygous L541P;A1038V (PV) missense mutation (Courtesy of Grace Jin, Case Western University, U.S.A.).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Retinal-specific ATP-binding cassette transporter (UniProt F1MWM0/P78363; also known as ATP-binding cassette sub-family A member 4, ABC transporter A4, RIM ABC transporter, RIM protein, RmP, Stargardt disease protein) is encoded by the ABCA4 (also known as ABCR) gene (Gene ID 281584/24) in bovine/human species
- ABC transporter A4, a ∽250kDa single-chain, is a multi-pass membrane protein of the superfamily of ATP-binding cassette (ABC) transporters that is localized to the disk margins of vertebrate photoreceptor outer segments
- It is implicated in the clearance of all-trans retinal derivatives from rod and cone photoreceptor cells following photoexcitation as part of the visual cycle
- ABC transporter A4 is composed of two symmetrically organized halves, each comprising six membrane-spanning helices, a large glycosylated exocytoplasmic domain located inside the disk, and a cytoplasmic domain with an ATP-binding cassette
- Mutations in ABCA4 are known to cause Stargardt macular degeneration, which is an autosomal recessive form of juvenile macular degeneration associated with a severe loss in vision
- Ref.: Tsybovsky, Y et al
- (2010)
- Adv
- Exp
- Med
- Biol
- 703, 105-125.