MilliporeSigma™ Cathepsin G, Mouse, Unlabeled, Clone: AHN-11,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT1240MI-Each-of-1 | In Stock | ₹ 42,968.31 |
MABT1240MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
Cathepsin G
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P08311
Immunogen
Human neutrophils.
Quantity
100 μg
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_001902
Target Species
Human
Form
Purified
Applications
Immunocytochemistry, Radioimmune Assays (RIA), Western Blot
Clone
AHN-11
Conjugate
Unconjugated
Gene
CTSG
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone AHN-11 reacted specifically with neutrophil cathepsin G, but not the homologous neutrophil neutral proteases, elastase, proteinase 3, or esterase N (Skubitz, K.M., et al. (1989). J. Leukoc. Biol. 46(2):109-118).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Cathepsin G (EC 3.4.21.20; UniProt P08311; also known as CatG, CG) is encoded by the CTSG gene (Gene ID 1511) in human
- Cathepsin G is a peptidase S1 protein family protease found in azurophil granules of neutrophilic polymorphonuclear leukocytes
- Cathepsin G displays a substrate specificity similar to that of chymotrypsin C, but it is most closely related to other immune serine proteases, such as neutrophil elastase and the granzymes
- Cathepsin G is involved in connective tissue remodeling at sites of inflammation
- Cathepsin G is also a component of neutrophil extracellular traps (NETs) composed of ejected lattice of chromatin enmeshed with granular and nuclear proteins, including histones, calprotectin and cathepsin G, that are capable of capturing and killing microbial invaders
- Antibodies raised against cathepsin G or histones have been shown to limit the bactericidal capacity of NETs towards pathogens
- Cathepsin G is prouduced with a signal peptide (a.a
- 1-18) and a propeptide sequence (a.a
- 19-20) that are removed posttranslationally to yield the mature (a.a
- 21-255) enzyme.