MABN844MI
MilliporeSigma™ Mouse anti-Neurophysin 1, Clone: PS 38,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN844MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABN844MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
Neurophysin 1
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
Oxt; Ot
Immunogen
KLH-conjugated acid soluble extract of rat (Sprague-Dawley) intermediate lobes corresponding to rat Neurophysin 1.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_037128
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG2b κ
Applications
Western Blot
Clone
PS 38
Gene Accession No.
P01179
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Rat
Form
Purified
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Description
- Specifically detects Neurophysin 1 clone: PS 38 in Rat samples, and it is validated for Western Blotting Neurophysins are linear cycteine-rich proteins containing 93-95 amino acids
- Two types of neurophysins, NPI and NPII are found in most mammalian species and they serve as carriers of oxytocin (OT) and vasopressin (AVP), respectively
- Each NP and its associated hormone is synthesized as one precursor protein, OT-NPI (UniProt P01179) encoded by the Oxt (or Ot) gene or VAP-NPII (UniProt P01186) encoded by the Avp gene in rat species
- Post-translational cleavages remove the signal peptide and process the precursor into mature OT and NPI (aa 20-28 and aa 32-135, respectively, of OT-NPI), or AVP and NPII (aa 24-32 and aa 36-128, respectively, of AVP-NPII)
- OT is a potent hormone and neurotransmitter secreted within the pituitary gland
- OT exerts its biological activity through its receptor OXTR (also known as OTR)
- OT is used clinically for labor induction and may exhibit therapeutic potential for treating social anxiety disorders
- VAP functions primarily as an anti-diuretic and regulates the concentration of water, glucose, and salts in blood
- VAP is secreted from the posterior pituitary, but exerts its biological activity in the kidney via the G protein-coupled receptor AVPR2 (V2R).