MABS529MI
MilliporeSigma™ Rat anti-MEKK5, Clone: TC003,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS529MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABS529MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
MEKK5
Classification
Monoclonal
Formulation
Purified rat monoclonal IgG2bκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
Map3k5; Ask1; Mekk5
Immunogen
Recombinant protein corresponding to the C-terminus of mouse MEKK5.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_032606
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG2b κ
Applications
Western Blot
Clone
TC003
Gene Accession No.
O35099
Host Species
Rat
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Mouse
Form
Purified
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Description
- Specifically detects MEKK5 clone: TC003 in Mouse samples, and it is validated for Western Blotting MEKK5 (MAP3K5) is a key kinase for our innate immunity and for mediating cellular signaling cascades evoked by changes in the external cellular environment
- As such, MEKK5 is critical for cell fate during development, apoptosis, and cell survival as well as in modulating the host defense responses from a wide range of pathogens
- MEKK5 acts as an upstream activator of the MKK/JNK signaling pathways and the p38 MAPK signaling pathways that ultimately results in activating multiple kinases such as MAP2K3/Mkk3 or MKK6/MMK7
- MEKK5 is inactive as an unphosphorylated homodimer, and MEKK5 binds both upstream activators and downstream substrates in multi-molecular complexes
- Expression is widespread and localized in the cytoplasmic in the perinuclear endoplasmic reticulum region, and MEKK5 is abundantly expressed in heart and pancreas
- MEKK5 is regulated via phosphorylation and ubiquitination and degradation via the proteasome.