MABN866MI
MilliporeSigma™ Mouse anti-Myocilin (NT), Clone: 7.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN866MI-Each-of-1 | In Stock | ₹ 42,114.80 |
MABN866MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,114.80
GST (18%): ₹ 7,580.664
Total Price: ₹ 49,695.464
Antigen
Myocilin (NT)
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
MYOC; GLC1A; TIGR
Immunogen
Recombinant protein corresponding to the N-terminal fragment (aa 33-214) of human Myocilin.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_000252
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunohistochemistry, Western Blot
Clone
7.1
Gene Accession No.
Q99972
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse
Form
Purified
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Description
- Specifically detects Myocilin (NT) clone: 7.1 in Human, Mouse samples, and it is validated for Immunohistochemistry, Western Blotting Myocilin (mutated trabecular meshwork-induced glucocorticoid response protein) is encoded by the MYOC gene (also known as GLC1A, GPOA, JOAG, JOAG1, TIGR) in human (Entrez Gene ID 4653)
- Myocilin is produced as a 504 amino acid glycoprotein containing an N-terminal hydrophobic signal peptide sequence, a coiled-coiled leucine zipper domain, and a C-terminal domain with homology to olfactomedins
- Myocilin is commonly identified as a 53/57kDa doublet by gel electrophoresis, and a 66kDa form of the protein is also reported
- Myocilin is known to undergo intracellular endoproteolytic cleavage between Glu214 and Leu215, resulting in a 20kDa N-terminal and a 35kDa C-terminal fragment
- Myocilin is identified as a Lingo-1 receptor ligand and MYOC gene mutations are linked to 10% of juvenile open-angle glaucoma cases and 3-4% of those with primary open-angle glaucoma (PMID 24732711 24741044, 24837143)
- Clone 7.1 is a mouse monoclonal antibody that recognizes an epitope within the N-terminal fragment (aa33-214) and is demonstrated to be suitable for Western blotting, immuncytochemistry, and immunhistochemistry applications
- This clone is reactive toward both human and murine species
- (PMID 18674535 & 23979599).