MilliporeSigma™ PCSK9, Mouse, Unlabeled, Clone: 9B3.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS434-Each-of-1 | In Stock | ₹ 42,969.20 |
MABS434 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,969.20
GST (18%): ₹ 7,734.456
Total Price: ₹ 50,703.656
Antigen
PCSK9
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Mouse IgG2a hybridoma culture supernatant without azide.
Gene Accession No.
Q8NBP7
Immunogen
GST-tagged recombinant human mature NARC-1 (PCSK9) N-terminal fragment.
Quantity
200 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_777596
Target Species
Human
Form
Culture Supernatant
Applications
Western Blot
Clone
9B3.1
Conjugate
Unconjugated
Gene
PCSK9, HCHOLA3, LDLCQ1, NARC1, PSEC0052
Host Species
Mouse
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 9B3.1 detects the precursor and mature forms of human PCSK9 (NARC-1) by targeting an epitope within the N-terminal region of the mature sequence.
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype
IgG2a κ
Related Products
Description
- Proprotein convertase subtilisin/kexin type 9 (UniProt Q8NBP7; also known as NARC-1, Neural apoptosis-regulated convertase 1, PC9, Proprotein convertase 9, Subtilisin/kexin-like protease PC9) is encoded by the PCSK9 (also known as HCHOLA3, LDLCQ1, NARC1, PSEC0052) gene (Gene ID 255738) in human
- PCSK9 is a proprotein convertase expressed in the hepatocyte and to a lesser extent also in the intestine and kidney
- PCSK9 is produced as a precusor protein with a signal peptide (a.a.1-30) and a propeptide sequence (a.a
- 31-152) that undergo posttranslational autocleavage to yield the mature PCSK9 protein (a.a
- 153-692)
- PCSK9 utilizes its proteolytic activity only in autocleavage during protein maturation, a process that is necessary for its secretion
- Once secreted into the plasma, PCSK9 binds LDL receptor (LDL-R), causing LDL-R endocytosis and lysosomal degradation, effectively reducing cell surface LDL-R population
- Both PCSK9 and LDL-R are transcribed by sterol-responsive element-binding protein 2 (SREBP2) in response to lowered cellular cholesterol level, allowing enhanced, but not unfettered cellular cholesterol uptake by LDL-R
- PCSK9 also binds very low density lipoprotein (VLDL) receptor and apolipoprotein E receptor 2, and thereby interferes with uptake of circulating VLDL particles and apolipoproteins.