MilliporeSigma™ Beta-Dystrobrevin, Mouse, Unlabeled, Clone: 6B5.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN1611-Each-of-1 | In Stock | ₹ 40,292.08 |
MABN1611 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
Beta-Dystrobrevin
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Mouse IgG1 hybridoma culture supernatant without azide
Gene Accession No.
O60941
Immunogen
GST-tagged recombinant internal fragment from the C-terminal half of human beta-dystrobrevin.
Quantity
100 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_068707
Target Species
Human
Form
Culture Supernatant
Applications
Western Blot
Clone
6B5.1
Conjugate
Unconjugated
Gene
DTNB
Host Species
Mouse
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 6B5.1 targeted epitope is present in human (spliced isoforms 1/3/4/6/7), mouse (isoforms 1 & 2), and rat beta-dystrobrevin reported by UniProt (O60941, O70585, P84060). Reactivity toward human spliced isoforms 2 and 5 that lack part of the immunogen sequence is possible, but has not been confirmed. Human isoforms 1, 2, and 3 are also known as DTN-B1, Dystrophin-associated protein A0, and DTN-B2, respectively.
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype
IgG1 κ
Related Products
Description
- Dystrobrevin beta (UniProt O60941; also known as Beta-dystrobrevin, DTN-B) is encoded by the DTNB gene (Gene ID 1838) in human
- Dystrobrevin alpha and beta are cytoplasmic components of dystrophin-associated glycoprotein complex (DGC) that links the extracellular matrix to the actin cytoskeleton
- Whereas dystrobrevin alpha is ubiquitously expressed, dystrobrevin beta is expressed in non-muscle tissues, including brain
- In addition to being a component of the DGCs, dystrobrevins also play roles in other functions via interact with various cellular proteins
- A role of dystrobrevin beta in the regulation of chromatin dynamics is suggested based on its interaction with the high mobility group-domain proteins iBRAF and BRAF35
- The function of dystrobrevins and their interactions with binding partners are regulated by post-translational modifications
- Both PKA and PKC are shown to phosphorylate dystrobrevin beta on Thr11 that negatively impacts its binding affinity for the cargo-binding domainof kinesin heavy chain (Kif5A)
- Dystrobrevin shares sequence homology with the C-terminus of dystrophin, but does not bind dystroglycan
- Dystrobrevin beta contains a ZZ-type zinc finger (a.a
- 237-284), syntrophin-binding region (a.a
- 399-448), a coiled-coil region (a.a
- 428-529) that mediates the association between dystrobrevin and dystrophin.