OP180100UG
MilliporeSigma™ anti-Noxa Clone: 114C307,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | OP180100UG-Each-of-1 | In Stock | ₹ 57,942.56 |
OP180100UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 57,942.56
GST (18%): ₹ 10,429.661
Total Price: ₹ 68,372.221
Antigen
Noxa
Classification
Monoclonal
Conjugate
Unconjugated
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Immunoblot
Clone
114C307
Formulation
In PBS, 0.05% BSA.
Immunogen
a recombinant protein consisting of human Noxa fused to GST
Regulatory Status
RUO
Test Specificity
Recognizes the ∽11kDa Noxa protein in RL-7 cells.
Content And Storage
−20°C
Isotype
IgG1
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Description
- Specifically detects Noxa Clone: 114C307 in Human samples, and it is validated for Immuno Blotting Noxa, a BH3 member of the Bcl-2 family, has recently been identified in human and mouse
- Expression of the Noxa gene involves direct activation of its promoter by p53
- Increased expression of Noxa occurs in normal thymocytes, but does not occur in p53-deficient thymocytes
- Coimmunoprecipitation data suggests that Noxa may interact with other members of the Bcl-2 family, including Bcl-X L and Mcl-1
- Data has also shown that blocking the endogenous Noxa induction results in the suppression of apoptosis
- Treating cells with Noxa antisense oligonucleotides blocks radiation-induced apoptosis, and this suggests that Noxa may be a mediator of p53-dependent apoptosis.