MilliporeSigma™ anti-c-Abl Clone: 24-21,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | OP20100UG-Each-of-1 | In Stock | ₹ 47,205.60 |
OP20100UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,205.60
GST (18%): ₹ 8,497.008
Total Price: ₹ 55,702.608
Antigen
c-Abl
Classification
Monoclonal
Conjugate
Unconjugated
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Form
Purified
Applications
Immunofluorescence, Immunoprecipitation
Clone
24-21
Formulation
In 0.05M sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Immunogen
a recombinant protein consisting of the carboxyl region of v-abl protein fused to TrpE
Regulatory Status
RUO
Test Specificity
Recognizes the ∽145kDa human c-Abl, the ∽150kDa mouse c-Abl, v-Abl, and the Bcr/Abl translocation products in ALL (∽190kDa) and CML (∽210kDa). Does not inhibit protein tyrosine kinase activity. Antibody Target Gene Symbol: ABL1 Target Synonym: ABL, AI325092, bcr/abl, C-ABL, C-ABL 1B, CABL1, E430008G22Rik, JTK7, MGC117749, p145Abl, p150, v-abl Entrez Gene Name: c-abl oncogene 1, receptor tyrosine kinase
Content And Storage
2°C to 8°C
Isotype
IgG1
Related Products
Description
- Specifically detects c-Abl Clone: 24-21 in Human, Mouse samples, and it is validated for Immunofluorescence, Immunoprecipitation The abl oncogene was initially identified as the viral transforming gene (v abl ) of Abelson murine leukemia virus (A-MuLV), from a chemically thymectomized mouse inoculated with Moloney murine leukemia virus (M MuLV)
- The v- abl genome consists of M-MuLV gag sequences fused to mouse c- abl , resulting in the production of phosphoproteins, p160 and p120 gag/c- abl with protein-tyrosine kinase activity, as the major translational products
- The abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic (CML), 20-25% of adult acute lymphoblastic (ALL), and 2-5% of pediatric ALL
- In these leukemias the c- abl proto-oncogene undergoes a chromosomal (9;22) translocation producing the Philadelphia (Ph1) chromosome resulting in the fusion of c- abl sequences to the bcr gene of chromosome 22
- The molecular consequences of this translocation is the generation of a chimeric bcr /c- abl mRNA encoding activated abl protein-tyrosine kinase.