Alpha A Crystallin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1009-Each-of-1 | In Stock | ₹ 42,987.00 |
PA1009 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,987.00
GST (18%): ₹ 7,737.66
Total Price: ₹ 50,724.66
Antigen
Alpha A Crystallin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CRYAA
Gene Alias
[a]A-crystallin; Acry 1; Acry-1; alpha A crystallin; alpha crystallin A chain; alpha-A-crystallin; alpha-crystallin A chain; Alpha-crystallin A(1-151); Alpha-crystallin A(1-156); Alpha-crystallin A(1-157); Alpha-crystallin A(1-162); Alpha-crystallin A(1-163); Alpha-crystallin A(1-165); Alpha-crystallin A(1-168); Alpha-crystallin A(1-172); Alpha-crystallin A2 chain; Alpha-crystallin A2(1-162); Alpha-crystallin A2(1-168); Alpha-crystallin A2(1-172); CRYA 1; Crya1; Crya-1; CRYAA; CRYAA2; Crystallin Alpha 1; crystallin alpha A; crystallin, alpha 1; crystallin, alpha A; Crystallin, alpha polypeptide A; crystallin, alpha-1; CTRCT9; DAcry-1; Heat shock protein beta-4; HSPB 4; HSPB4; human alphaA-crystallin (CRYA1); lens opacity 18; LOC102724652; lop18; small heat shock protein; wu:fc06h04; zgc:92036
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
24273, 281718
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Lyophilized
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 30mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P02470, P24623
Gene Symbols
CRYAA
Immunogen
Purified alpha-A Crystallin from bovine lens.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-009 detects alpha-A crystallin from bovine and rat samples
- This antibody does not detect the unphosphorylated form of the protein
- PA1-009 has been successfully used in Western blot and immunohistochemistry procedures
- By Western blot, this antibody detects an ∽20 kDa protein representing alpha-A crystallin from bovine lens samples
- Immunohistochemical staining of alpha-A crystallin in rat thymus samples results in staining of epithelial reticular cells
- The PA1-009 immunogen is purified alpha-A Crystallin from bovine lens
- Reconstitute in 100 μL PBS to create a stock of 1 mg/mL
- Lens proteins consist almost entirely of crystallins (about 95%)
- Crystallins are also found vertebrate skeletal muscle tissue
- In the lens, their structural function is to assist in maintaining the proper refractive index of the lens
- The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma
- Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B
- There are at least 5 different proteins comprising the beta-crystallins
- The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens
- Alpha-Crystallin comprises 40% of total lens protein composition
- In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation
- It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance
- Alpha-B crystallin has been linked to Alexander's disease where it accumulates in brain cells of those afflicted.