Leptin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1052-Each-of-1 | In Stock | ₹ 48,282.50 |
PA1052 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,282.50
GST (18%): ₹ 8,690.85
Total Price: ₹ 56,973.35
Antigen
Leptin
Classification
Polyclonal
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
P41159, P41160, Q29406
Gene Symbols
Lep
Immunogen
Synthetic peptide corresponding to residues S(91) R N V I Q I S N D L E N L R D(106) of human Leptin.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Porcine
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Conjugate
Unconjugated
Gene
Lep
Gene Alias
CD295 antigen; H-Leptin; HuB219; Lep; LEPD; LEP-R; Leptin; leptin (murine obesity homolog); leptin (obesity homolog, mouse); leptin precursor; Method: conceptual translation supplied by author.; OB; obese; obese protein; obese, mouse, homolog of; obesity; obesity factor; obesity protein; OB-R; OBS; truncated leptin
Host Species
Rabbit
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
16846, 3952, 396832
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
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Description
- PA1-052 detects leptin from human, mouse, and porcine samples
- PA1-052 has been successfully used in Western blot and ICC/IF procedures
- By Western blot, this antibody detects an ∽16 kDa protein representing leptin from human serum
- The PA1-052 immunogen is a synthetic peptide corresponding to residues S(91) R N V I Q I S N D L E N L R D(106) of human Leptin
- This sequence is 94% conserved between human and bovine
- Leptin is a 167 amino acid long protein hormone with important effects in regulating body weight, metabolism and reproductive function
- Leptin is approximately 16 kDa in mass and encoded by the obese (ob) gene
- Leptin is expressed predominantly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body
- Smaller amounts of leptin are also secreted by cells in the epithelium of the stomach and in the placenta
- Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells
- Leptin's effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure
- Leptin is involved in regulating food intake, energy expenditure, and adiposity through hypothalamic leptin receptors
- Leptin promotes hematopoiesis, angiogenesis, wound healing, inflammation, immune responses, influences pubertal development and fetal growth
- Studies have investigated the role of leptin in obesity, anorexia nervosa, insulin resistance, and hypertension
- Leptin also has thermogenic actions and regulates enzymes of fatty acid oxidation
- Severe hereditary obesity in rodents and humans can be caused by defects in leptin production.