AHR Monoclonal Antibody (RPT9), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA1513-Each-of-1 | In Stock | ₹ 48,282.50 |
MA1513 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,282.50
GST (18%): ₹ 8,690.85
Total Price: ₹ 56,973.35
Antigen
AHR
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
antibody with 0.05% sodium azide
Gene Accession No.
P30561, P35869, P41738
Gene Symbols
AHR
Immunogen
Synthetic peptide corresponding to residues R(12) K R R K P(17) V(22) K P I P A E G I K(31) of mouse AhR.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG3 κ
Applications
ChIP Assay, Flow Cytometry, Gel Shift, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Clone
RPT9
Conjugate
Unconjugated
Gene
AHR
Gene Alias
Ah; Ah receptor; Ahh; Ahr; Ahre; AH-receptor; aromatic hydrocarbon receptor; aryl hydrocarbon receptor; aryl-hydrocarbon receptor; bHLHe76; Class E basic helix-loop-helix protein 76; dioxin receptor; In
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
11622, 196, 25690
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- MA1-513 detects the aryl hydrocarbon receptor (AhR) from human, mouse, and rat cells
- MA1-513 has been successfully used in immunoprecipitation, chromatin immunoprecipitation, immunocytochemistry, immunohistochemistry, immunofluorescence, and gel shift procedures
- This antibody specifically immunoprecipitates a single ∽95 kDa protein representing AhR from Hepa 1 cytosol
- Although MA1-513 can be used in Western blotting procedures, MA1-514 (clone RPT1) is recommended for this procedure
- The MA1-513 immunogen is a synthetic peptide corresponding to residues R(12) K R R K P(17) V(22) K P I P A E G I K(31) of mouse AhR
- AHR (Ah Receptor) belongs to a family of proteins comprised of its dimerization partner ARNT (HIF-1 Beta) and the Drosophila proteins PER and SIM
- AHR contains an N-terminal sequence of approximately 200 amino acids termed the PAS domain
- AHR, found in a variety of tissues, binds to a specific DNA enhancer sequence and initiates transcription of the mRNA for the cytochrome P-450 (CYPIA1) gene
- The gene for AHR encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons
- AHR has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450, and its ligands included a variety of aromatic hydrocarbons
- AHR is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species
- The known ligands for AHR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
- Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for AHR
- Studies indicate that in non-ligand activated cells, AHR is found complexed with HSP90 predominantly in the cytoplasm
- Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form, and this transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt)
- Diseases associated with AHR include eosinophilic fasciitis and seborrheic dermatitis.