Leptin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1051-Each-of-1 | In Stock | ₹ 51,086.00 |
PA1051 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,086.00
GST (18%): ₹ 9,195.48
Total Price: ₹ 60,281.48
Antigen
Leptin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Lep
Gene Alias
CD295 antigen; H-Leptin; HuB219; Lep; LEPD; LEP-R; Leptin; leptin (murine obesity homolog); leptin (obesity homolog, mouse); leptin precursor; Method: conceptual translation supplied by author.; OB; obese; obese protein; obese, mouse, homolog of; obesity; obesity factor; obesity protein; OB-R; OBS; truncated leptin
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16846, 25608, 3952, 443534
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ChIP Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
Concentration
2 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P41159, P41160, P50596, Q28603
Gene Symbols
Lep
Immunogen
Synthetic peptide corresponding to residues Q(25) K V Q D D T K T L I K T I V T R I N D(44) of mouse Leptin.
Quantity
50 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Ovine, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-051 detects leptin from human, mouse, sheep and rat samples
- PA1-051 has been successfully used in Western blot, immunocytochemistry and immunohistochemistry experiments
- By Western blot, this antibody detects an ∽16 kDa protein representing leptin from 3T3-L1 cell extract
- Immunohistochemical staining of leptin in sheep brain with PA1-051 results in staining of the ventromedial hypothalamus
- The PA1-051 immunogen is a synthetic peptide corresponding to residues Q(25) K V Q D D T K T L I K T I V T R I N D(44) of mouse Leptin
- This sequence is completely conserved between mouse and bovine
- Leptin is a 167 amino acid long protein hormone with important effects in regulating body weight, metabolism and reproductive function
- Leptin is approximately 16 kDa in mass and encoded by the obese (ob) gene
- Leptin is expressed predominantly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body
- Smaller amounts of leptin are also secreted by cells in the epithelium of the stomach and in the placenta
- Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells
- Leptin's effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure
- Leptin is involved in regulating food intake, energy expenditure, and adiposity through hypothalamic leptin receptors
- Leptin promotes hematopoiesis, angiogenesis, wound healing, inflammation, immune responses, influences pubertal development and fetal growth
- Studies have investigated the role of leptin in obesity, anorexia nervosa, insulin resistance, and hypertension
- Leptin also has thermogenic actions and regulates enzymes of fatty acid oxidation
- Severe hereditary obesity in rodents and humans can be caused by defects in leptin production.